Pharmaceutical Name

Trade (marketing or proprietary) name: GLUCOPHAGE®, Fortamet®, Glumetza®, Riomet®, and Trijardy® (as a combination product containing Empagliflozin, Linagliptin, Metformin). Metformin may be present in combination products as well. For the full list, go to this NIH link.

Generic (nonproprietary or active ingredient) name: metformin hydrochloride

Indication and Usage

Reason the product has been approved for sale on the market.

FDA has approved this prescription medication as an adjunct to diet and exercise to improve glycemic control in adults and children with type 2 diabetes mellitus.

Manufacturer Insert

Ingredients

GLUCOPHAGE tablets contain 500 mg, 850 mg, or 1000 mg of metformin hydrochloride. Each tablet contains the inactive ingredients povidone and magnesium stearate. In addition, the coating for the 500 mg and 850 mg tablets contains hypromellose and the coating for the 1000 mg tablet contains hypromellose and polyethylene glycol. GLUCOPHAGE XR contains 500 mg or 750 mg of metformin hydrochloride as the active ingredient. GLUCOPHAGE XR 500 mg tablets contain the inactive ingredients sodium carboxymethyl cellulose, hypromellose, microcrystalline cellulose, and magnesium stearate. GLUCOPHAGE XR 750 mg tablets contain the inactive ingredients sodium carboxymethyl cellulose, hypromellose, and magnesium stearate.

Manufacturer-Listed Adverse Reactions

Per the CDC, adverse reactions are an undesirable medical condition that has been demonstrated to be caused by a vaccine. Evidence for the causal relation is usually obtained through randomized clinical trials, controlled epidemiologic studies, isolation of the vaccine strain from the pathogenic site, or recurrence of the condition with repeated vaccination (i.e., rechallenge); synonyms include side effect and adverse effect.

Metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. Decrease to subnormal levels of previously normal serum vitamin B12 levels, Cholestatic, Hepatocellular, Mixed hepatocellular liver injury, Diarrhea, Nausea/Vomiting, Abdominal pain, Constipation, Distention abdomen, Palpitation, Changes in your blood sugar, Unpleasant metallic taste in mouth, Sweating increased, Taste disorder, Chest discomfort, Chills, Flu syndrome, Flushing, Dyspnea, Nail disorder, Rash, Hypoglycemia, Myalgia, Lightheade, Dyspepsia/heartburn, Flatulence, Dizziness, Headache, Abnormal stools, Upper respiratory infection, Taste disturbance, and Asthenia

Analytical Deep Dive

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