Pharmaceutical Name

Trade (marketing or proprietary) name: Lupron Depot – Ped

Generic (nonproprietary or active ingredient) name: Leuprolide acetate

Indication and Usage

Reason the product has been approved for sale on the market.

FDA has approved this injection for the treatment of children with central precocious puberty. This is used off label (not according to manufacturer guidance) as a hormone blocker.

Manufacturer Insert

Manufacturer-Listed Adverse Reactions

Per the CDC, adverse reactions are an undesirable medical condition that has been demonstrated to be caused by a vaccine. Evidence for the causal relation is usually obtained through randomized clinical trials, controlled epidemiologic studies, isolation of the vaccine strain from the pathogenic site, or recurrence of the condition with repeated vaccination (i.e., rechallenge); synonyms include side effect and adverse effect.

Lupron can cause: Rash/urticaria (hives)/photosensitivity, Localized reactions at injection site including induration and abscess, Hypotension, Decreased WBC (white blood cells), Peripheral neuropathy, Convulsion, Spinal fracture/paralysis, Tenosynovitis-like symptoms (inflammation of the membrane surrounding tendons), Prostate pain, Pituitary apoplexy (sudden headache, vomiting, visual changes, ophthalmoplegia, altered mental status, and sometimes cardiovascular collapse. Immediate medical attention has been required), Symptoms consistent with fibromyalgia (e.g., joint and muscle pain, headaches, sleep disorders, gastrointestinal distress, and shortness of breath) have been reported individually and collectively, Pulmonary embolism (blockage of an artery in the lungs by a substance that has moved from elsewhere in the body through the bloodstream), Hepatic (liver) dysfunction, Hair growth, Hearing disorder, Hard nodule in throat, Weight gain, Increased uric acid, Respiratory disorders, Decreased bone density, Mood swings, Depression, Suicidal ideation and attempt, Myocardial infarction (heart attack), Interstitial lung disease, Serious drug-induced liver injury, Diabetes

Analytical Deep Dive

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